Professeure adjointe

Vanessa Houde

Microbiologie et immunologie buccales

Pavillon de médecine dentaire, local 1716

418 656-2131, poste 415147

vanessa.houde@fmd.ulaval.ca

Formation universitaire
Post-doctorat en métabolisme et cancer, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada 2016
Post-doctorat en biologie et cancer, MRC Protein Phosphorylation Unit, University of Dundee, Dundee, Royaume Uni 2013
Doctorat en physiologie-endocrinologie (PhD), Centre de recherche de l’Institut universitaire de cardiologie et pneumologie de Québec, Faculté de médecine, Université Laval, Québec 2011
Maîtrise en microbiologie (M.Sc), Groupe de recherche en écologie buccale (GREB), Faculté des sciences et de génie, Université Laval, Québec 2006
Baccalauréat en microbiologie (B.Sc), Faculté des sciences et de génie, Université Laval, Québec 2004
Publications récentes
  1. M. Shum, V.P. Houde, V. Bellemare, R.J. Moreira, K. Bellmann, P. St-Pierre, M. Pende, M. Foretz, B. Viollet, A. Marette. Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells. JBC, 2019 Aug 9;294(32):12250-12260.
  2. J.S.V. Lally, S. Ghoshal, D.K. DePeralta, O. Moaven, L. Wei, R. Masia, D.J. Erstad, N. Fujiwara, V. Leong, V.P. Houde, et al. Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. Cell Metabolism. 2019; 29, 1–9.
  3. V.P. Houde, S. Donzelli, A. Sacconi, S. Galic, J.A. Hammill, J.L. Bramson, R.A. Foster, T. Tsakiridis, B.E. Kemp, G. Grasso, G. Blandino, P. Muti and G.R. Steinberg. AMPK β1 reduces tumor progression and improves survival in p53 null mice. Molecular Oncology. 2017: 11: 1143–1155.
  4. L.A. Villani, B.K. Smith, K. Marcinko, R.J. Ford, L.A. Broadfield, A.E. Green, V.P. Houde, P. Muti, T. Tsakiridis, G.R. Steinberg. The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration. Molecular Metabolism. 2016; 5: 1048e1056.
  5. B.K. Smith, R.J. Ford, E.M. Desjardins, A.E. Green, M.C. Hughes, V.P. Houde, E.A. Day, K. Marcinko, J.D. Crane, E.P. Mottillo, C.G.R. Perry, B.E. Kemp, M.A. Tarnopolsky and G.R. Steinberg. Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK β1. Diabetes. 2016; 65: 3352–3361.
  6. G. Hoxhaj, E. Caddye, A. Najafov, V.P. Houde, C. Johnson, K. Dissanayake, R. Toth, D.G. Campbell, A.R. Prescott, C. MacKintosh. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids. eLife 2016;5:e12278.
  7. A.J. O’Brien, L.A. Villani, L.A. Broadfield, V.P. Houde, S. Galic, G. Blandino, B.E. Kemp, T. Tsakiridis, P. Muti, G.R. Steinberg. Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis. Biochemical Journal. 2015; 469: 177-187.

Conférences et communications scientifiques récentes (5 dernières années)

  1. N. Daniel, B. S.-Y. Choi, V. P. Houde, C. Vors, T. Varin, P. St-Pierre, A. Marette. Dietary proteins relevant to human consumption impact the development of obesity and type 2 diabetes in association with major changes in the gut microbiota in a mouse model. Nutrition 2019, Baltimore, Maryland, USA, June 8th-11th, 2019.
  2. A. Morissette, C. Kropp, S. Dudonné, T. Varin, Y. Desjardins, V.P. Houde, G. Pilon and A. Marette. Evaluation of the protective effects of blueberry, anthocyanin and proanthocyanidin diets against obesity associated disorders and gut microbiota dysbiosis in a mouse model of diet-induced obesity. Berry Health Benefits Symposium, Portland, Oregon, USA, May 7th-9th, 2019.
  3. R. Durand, E. Fraboulet, G. Pilon, V.P. Houde, T. Varin, A. Marette and L. Bazinet. Use of herring milt hydrolysate for the improvement of the metabolic syndrome: in vitro and in vivo experiments. International BIPROSP-19, Tromso, Norway, February 2019
  4. A. Morissette, C. Kropp, S. Dudonnée, V.P. Houde, V.P, G. Pilon, Y. Desjardins, A. Marette. Impact des polyphénols de bleuets sur les désordres métaboliques dans un modèle de souris obèse. Journée de la recherche en santé de la Faculté de Médecine, Université Laval, Québec, Qc, 23-24 mai 2018.
  5. C. Kropp, A. Morissette, S. Dudonné, Y. Desjardins, V.P. Houde, G. PILON, A. Marette. Impact des polyphénols de bleuets sur les désordres métaboliques dans un modèle de souris obèse. Congrès SQLNM, Magog, Qc, 7-9 février 2018.
  6. C. Kropp, S. Dudonné, Y. Desjardins, V.P. Houde, G. Pilon, A. Marette. Impact of blueberry polyphenols against metabolic disorders in a mouse model of diet induced-obesity. ICPH 2017: International Conference on Polyphenols and Health 2017, Octobre 2017, Québec, Canada.
  7. V.P. Houde, S. Donzelli, A. Sacconi, S. Galic, J.A. Hammill, J.L. Bramson, R.A. Foster, T. Tsakiridis, B.E. Kemp, G. Grasso, G. Blandino, P. Muti and G.R. Steinberg. AMPK β1 reduces tumorigenesis in p53-null mice. McMaster Oncology research day. McMaster University, Hamilton, Ontario, June 23rd 2016.
  8. V.P. Houde, J.A. Hammill, J.L. Bramson, G. Blandino, T. Tsakiridis, G.R. Steinberg, P. Muti. Investigating the link between the p53 and AMPK signaling pathways in a mouse model of T cell lymphoma. ECRI Research Day, Hamilton, ON, Jan 30, 2015
Projets de recherche
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