Professeur titulaire

Ze Zhang

Biomatériaux, prothèses vasculaires, polymères conducteurs

Hôpital Saint François d’Assise, local E00-177

418 525-4416

Formation universitaire
Post doctorat en prothèse vasculaire, Institut national de recherche sur les biosciences et la technologie humaine, Japon. 1995
Ph.D. en Médecine expérimentale, Université Laval. 1993
M.Eng. en Génie biomédicale, Université des sciences et technologies de Chengdu, Chine. 1984
B.Eng. en Ingénierie plastique, Université des sciences et technologies de Chengdu, Chine. 1982
  • Synthèse et caractérisation des biomatériaux
  • Biomatériaux électriquement conducteurs
  • Développement et évaluation des prosthèses vasculaires
  • Évaluation des explants cardiovasculaires
  • Stimulation électrique des cellules
Publications récentes
  1. Shujun Cui, Jifu Mao, Mahmoud Rouabhia, Saïd Elkoun, Ze Zhang. A biocompatible polypyrrole membrane for biomedical applications. RSC Adv., 2021; 11: 16996–17006.
  2. Qian Zhang, Yimeng Li, Jianhua Zhu, Lizhen Lan, Chaojing Li, Jifu Mao, Fujun Wang, Ze Zhang, Lu Wang. Ultra-low temperature flexible supercapacitor based on hierarchically structured pristine polypyrrole membranes. Chem. Eng. J., 2021 Sept; 420 part 1: 129712.
  3. Fujun Wang, Chaojing Li, Robert Guidoin, Abedalwafa Mohammed, Graeham Douglas, Fan Zhao, Guy Dionne, Ze Zhang, Haripriya Ramesh, Lu Wang, Mark Nutl Customized and in Situ Fenestrated Stent-grafts: a Reinforced Poly-ε-caprolactone Branch Cuff Designed to Prevent Type III Endoleaks and Enhance Hemodynamics. Medicine in Novel Technology and Devices. 9: 100055, 2021.
  4. Jing Lin, Limael E. Rodriguez, Mark Nutley, Lu Jun, Ying Mao, Niraj Parikh, Fanny Alie-Cusson, Ze Zhang, Lu Wang, Jean M. Panneton, Robert Guidoin. Optimal in-situ fenestration technique with laser perforation and balloon angioplasty for aortic stent-grafts. Journal of Endovascular Therapy. Accepted on Nov 8, 2020.
  5. Jing LIN, Mark NUTLEY, Chaojing LI, Graeham DOUGLAS, Jia DU, Ze ZHANG, Yvan DOUVILLE, Robert GUIDOIN, Lu WANG. Innovative textile structures designed to prevent type III endoleaks in endovascular stent-grafts. Artificial Organs, Sept 2020. Accepted.
  6. Yiwei Tong, Guillaume Febrer, Jifu Mao, Paul Wawryko, Ying Mao, Gaëtan Le-Bel, Daniel How, Eric Philippe, Tianyi Zhou, Ze Zhang, Lu Wang, Lucie Germain, Robert Guidoin. Limb salvage after aneurysmal degeneration of a cryopreserved vein allograft:searching the autologous veins of the arm is worth the effort. Morphologies, Sept. 2020; 104:202-213.
  7. Mahmoud Rouabhia, Hyun Jin Park, Atieh Abedin-Do, Yvan Douville, Mireille Méthot, Ze Zhang. Electrical stimulation promotes the proliferation of human keratinocytes, increases the production of keratin 5 and 14, and increases the phosphorylation of ERK1/2 and p38 MAP kinases. J Tissue Eng Regen Med. July 2020; 14(7):909-919.  doi: 10.1002/term.3040. 
  8. Aisa Rassoli, Yiming Li, Xianhao Bao, Fabien Kawecki, Xinzhe Zhao, Daniel Chappard, Gaëtan le-Bel, Jiaxuan Feng, Benedikt Weber, Nasser Fatouraee, Ze Zhang, Zaiping Jing, Lucie Germain, Lu Wang, Robert Guidoin. Donkey pericardium as a select sourcing to manufacture percutaneous heart valves: Decellularization has not yet demonstrated any clear cut advantage to glutaraldehyde treatment. Medicine in Novel Technology and Devices 2019; 4:
  9. Li, Chaojing, Mao, Jifu, Li, Qiwei, Wang, Fujun, Jiao, Yongjie, Zhang, Ze, Guidoin, Robert, Wang, Lu. Long-term anticoagulation and selective cells adhesion surface via combination of covalent grafting and layer by layer assembly. Biomedical Materials. 2019 Oct 8;14(6):065012. doi: 10.1088/1748-605X/ab452b.
  10. Aisa Rassoli, Nasser Fatouraee, Robert Guidoin, Ze Zhang. Comparison of tensile properties of xenopericardium from three animal species and finite element analysis for bioprosthetic heart valve tissue. Artificial Organs, accepted on August 2, 2019.
  11. Jifu Mao, Aisa Rassoli, Yiwei Tong, Elizabeth Nicole Rouse, Gaёtan Le-Bel, Daniel How, Lucie Germain, Nasser Fatouraee, Ze Zhang, Robert R. Reed, Robert Guidoin. Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcutaneous heart valves. Artificial Organs, published on May 29, 2019. org/10.1111/aor.13503
  12. Hanen Jannadi, Wilmar Correa, Ze Zhang, Klaus Brandenburg, Ridha Oueslati, Mahmoud Rouabhia. Antimicrobial peptides Pep19–2.5 and Pep19-4LF inhibited Streptococcus mutans growth and biofilm formation. Microbial Pathogenesis, accepted, May 2019. doi: 10.1016/j.micpath.2019.103546
  13. Meng S, Mao J, Rouse EN, Le-Bel G, Bourget JM, Reed RR, Philippe E, How D, Zhang Z, Germain L, Guidoin R. The Red Kangaroo pericardium as a material source for the manufacture of percutaneous heart valves. Morphologie. 2019. S1286-0115(18)30282-0, doi: 10.1016/j.morpho.2018.12.004.
  14. Jifu Mao, Mahmoud Rouabhia, Ze Zhang. Surface Modification by Assembling: A Modular Approach Based on Match in Nanostructures. Journal of Materials Chemistry B, 2019, 7, 755 – 762, DOI: 10.1039/C8TB02789G.
  15. Shurui Liao, Qiang He, Lie Yang, Shuai Liu, Ze Zhang, Robert Guidoin, Qiang Fu, Xingyi Xie. Towards endothelialisation via vascular endothelial growth factor immobilisation on cell-repelling functional polyurethanes. J Biomed Mater Res Part B Appl Biomater. 2019 May; 107(4):965-977. doi: 10.1002/jbm.b.34190.
Conférences et communications scientifiques récentes
  1. Ze Zhang. Electrical conductivity: A new dimension in scaffolding. 11th World Biomaterials Congress, December 11 – 15, 2020. Virtual. Keynote.
  2. Mahmoud Rouabhia, Yvan Douville, Mireille Méthot, and Ze Zhang. Heparin-bio-activated PPy/PLLA conductive membranes increased keratinocyte proliferation and the secretion of EGF and VEGF. 11th World Biomaterials Congress, December 11 – 15, 2020. Virtual.
  3. Shujun Cui, Mahmoud Rouabhia, Ze Zhang. Polypyrrole membrane reinforced with electrospun PU/PLLA fibres for biomedical applications. 11th World Biomaterials Congress, December 11 – 15, 2020. Virtual. (Oral)
  4. Jifu Mao, Shujun Cui, Mahmoud Rouabhia, Ze Zhang. A monocomponent polypyrrole membrane with super-flexibility and stable conductivity for biomedical applications. 11th World Biomaterials Congress, December 11 – 15, 2020. Virtual.
  5. Atieh Abedin Do, Ze Zhang, Mahmoud Rouabhia. The use of conductive PPy-PLLA membrane to investigate the effect of electrical stimulation on diabetic human skin fibroblasts. 11th World Biomaterials Congress, December 11 – 15, 2020. Virtual.
  6. Dingkun Wang, Zhiyong Du, Ze Zhang. The dual roles of proanthocyanidins in cultured vascular endothelial cells. TBIS2019, Suzhou, China. Sept. 8 – 11, 2019. (Invited talk, Medal Speaker)
  7. Ze Zhang, Jifu Mao, Mahmoud Rouabhia. Nano-structured polypyrrole. The 6th Nano Today Conference, Lisbon, Portugal. June 16 – 20, 2019. (Oral)
  8. Shujun Cui, Mahmoud Rouabhia, Ze Zhang. A soft and electrically stable polypyrrole membrane reinforced with electrospun fibres for biomedical applications. The 35th Annual Meeting of the Canadian Biomaterials Society, Quebec, QC, Canada. May 21-24, 2019.
  9. Ze Zhang. The potential of using polyphenols in medical implants. MedTex19&IFBMTM 2019, Shanghai, China. May 16 – 18, 2019. (Invited talk)
Autres activités

Membre régulier du Groupe de recherche en écologie buccale

Membre régulier du l’Axe médecine régénératrice, CHU-Université Laval

Membre régulier du Centre de recherche sur les systèmes polymères et composites à haute performances

Membre de Société Canadienne des biomatériaux

Expert du projet 111 sur les textiles biomédicaux, Université Donghua